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Metal ions such as Fe 2+/3+ , Cu +/2+ , Zn 2+ , Ni 2+ and other transition metal ions are often able to form stable coordination compounds with multiple coordination sites in natural products due to their variable oxidation states and strong field strengths

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(228) reviewed the interactions between mitochondrial dynamics and metabolic function, focusing on one of the key GTPases required for mitochondrial fusion, mitofusin-2 (Mfn2)

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