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The brain-gut axis has emerged as a crucial bidirectional pathway connecting the brain and the gastrointestinal (GI) system through an intricate network of neuronal, hormonal, and immunological pathways

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Combined with its ability to enter the brain, Cu-ATSM may be an attractive investigational product for clinical trials of ferroptosis and neurodegeneration

In addition to the regulation of GPX4, the level of lipid peroxides in cells can also be regulated by lipoxygenase [17, 78]

Other pharmacologic treatments included other opioids, alpha2-adrenergic agonists, anxiolytics, an herbal supplement, and placebo
