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Systemically delivered amitriptyline produced even more durable effects, maintaining synaptic integrity in treated animals for up to 1 year post-treatment (Fernandez et al., 2021), underscoring the translational potential of TrkB-based strategies for auditory synaptopathy, a key pathological substrate of tinnitus

Caffeine toxicity in forensic practice: Possible effects and under-appreciated sources

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However, females in different situations, such as multiple blood sampling, which thus have different effects, may take different mechanism routes

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Some patients continue with weekly injections for 6 months or longer, then transition to biweekly or monthly maintenance