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Shai SY, Sukhanov S, Higashi Y, Vaughn C, Kelly J, Delafontaine P

10.3390/biom12010056 131 van der PollT.van de VeerdonkF
Of greater significance, though, is the uncoupling of the enzyme aconitase, the major enzyme involved in the metabolism of citrate in the citric acid

Additionally, combination therapy studies indicate that ITCs can sensitize tumors to conventional chemotherapy and overcome drug resistance, thereby improving therapeutic outcomes when used as adjuncts (130)

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