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*Correspondence: Julien Baruteau, [email protected] This article was submitted to Drug Metabolism and Transport, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Internalization of the IF and vitamin B12 complex results in the release of the complex from its receptor and passage into the bloodstream [9]

In cardiac surgery, direct contact between blood and the CPB circuit induces an inflammatory response mediated by cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-) [3, 11]

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Amniotic tissue graft has been used in a variety of applications in the past 100 years with positive results and no adverse effects reported in the literature