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They were then fixed in formalin and processed for histologic and histochemical evaluation and morphometry

Selected well-studied and highly enriched ER proteins are denoted with gene names

[18] constructed an osteoporosis model by ovariectomy and administered total flavonoids of Rhizoma drynariae (TFRD) via gavage to upregulate the mRNA expression levels of Wnt3, LRP-5, -catenin and Runx2, as well as the protein expression of Wnt3, LRP-5 and -catenin in the tibia tissue of rats with osteoporosis, thereby attenuating the structural damage of bone tissue

We highlight recent progress in the discovery of selective inhibitors, dual-target inhibitors, allosteric modulators, covalent inhibitors, proteolysis-targeting chimeras (PROTACs), and protein-protein interaction (PPI) modulators

[PubMed: 15972685] 355

doi: 10.3390/life13040998 78 Salvador-ColomaCSantaballaASanmartnECalvoDGarcaAHervsDet al