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Lee E, et al

Among these, syn oligomers (synOs) are considered highly neurotoxic due to their ability to induce mitochondrial dysfunction, impair synaptic transmission, damage cellular membranes, and trigger intracellular inflammation and lysosomal stress [11]

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5,6 Alpha-ketoglutarate is used to make glutamate the main amino-group donor for transamination reactions
10.3390/cosmetics11040118
