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The stimulation of the Met receptor with HGF causes the translocation of MACC1 from the cytoplasm into the nucleus

10.3389/fphar.2025.1547131 313 ZhaoY.YanJ.ZhuY.HanZ.LiT.WangL

Walter, C

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Interestingly, a xCT inhibitor, HG106 was identified that does not induce ferroptosis but apoptosis, indicating potential off-targets or cell-type specific response [83]

Mechanistically, it activates autophagy, thereby reducing oxidative stress and inflammationcritical contributors to the pathogenesis of aging and chronic diseasesas well as hormonal changes, including elevated growth hormone levels and reduced insulin levels, which contribute to maintaining metabolic homeostasis