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The 2025 narrative review noted that despite the volume of preclinical work, well-controlled human trial data are scarce, and the regenerative findings should be interpreted accordingly (PMID 40789979)

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Therefore, vitamin B12 supplements are recommended for dogs with digestive ailments, including long-term diarrhea or chronic colitis, inflammatory bowel disease (IBD), and exocrine pancreatic insufficiency (EPI)

Commonly observed inherited genetic conditions that can increase cancer risk include familial adenomatous polyposis (FAP), Lynch syndrome, Li-Fraumeni syndrome, von Hippel-Lindau (VHL), BRCA1 and 2 mutations, multiple endocrine neoplasia, and more