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The break is not required for safety or receptor resensitization, but it allows for reassessment and prevents indefinite use of a compound with limited long-term human data

The inclusion of participants experiencing these hormonal changes may be another limitation of the study

doi: 10.1038/s41592-020-00981-9 [DOI] [PMC free article] [PubMed] [Google Scholar] Associated Data This section collects any data citations, data availability statements, or supplementary materials included in this article

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Lipotropic nutrients help mobilise and burn fat for energy