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His/her insightful comments and constructive suggestions were invaluable in refining our manuscript (Hidouri et al., 2024[51])

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Its cerebral levels show a positive correlation with amyloid plaque burden, with SMOC1 co-localizing on plaque surfaces in late-stage AD

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This ROS-driven cascade converges on microvascular dysfunctioncharacterized by dysregulated vasodilation, compromised endothelial barrier function, and increased vascular fragilityultimately manifesting as mucosal erosions and hemorrhage, the hallmark features of PHG [373]