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While this is part of how they help with appetite and weight, it can also lead to: Acid reflux A feeling of fullness or pressure Disrupted sleep (especially if reflux worsens at night) Even if youve been taking Akkermansia, it may not fully offset this effect because the root issue here is mechanical (slower stomach emptying) rather than purely microbial

10.1016/j.alcohol.2006.06.013 170 ZhouZ.KarlssonC.LiangT.XiongW.KimuraM.TapocikJ

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Keep it on for up to 8 hours for best results

In Zhous study, the fixed-effects model was applied to calculate the pooled effect size even though significant heterogeneity (51%) was observed among the studies

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