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Unlike standard doses that produce sustained opioid receptor blockade, LDN transiently blocks opioid receptors, leading to a paradoxical upregulation of the endogenous opioid system and modulation of immune responses

Although IV therapy is generally well-tolerated, potential risks include minor bruising at the injection site, allergic reactions, infections, or electrolyte imbalances

[PubMed] [Google Scholar] Davey A

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