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2017 Nov 22;9(11):1270

As the unconventional XBP1 mRNA splicing by IRE1 and the subsequent activation of the spliced XBP1 protein expression are the major mechanism of ER homeostasis regulation by IRE1 10 , we tested whether XBP1 plays a role in IRE1-mediated ferroptosis sensitization

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doi: 10.1007/s13668-022-00432-1 168 MtGBernsteinLRTrkAL

In RA, this translates to Glutathione and joint pain relief, as restored levels dampen hypersensitivity [11]