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OCTN2 also plays a substantial role in carnitine trafficking between the tissues

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6) Pregnancy Sex hormones during pregnancy increase FMO3 enzyme activity, which can increase TMAO [54]

Therefore, there is a potential risk for the children of developing countries who consume grain-based diets as their staple food to receive inadequate amounts of available lysine compared to the established daily intake levels [12]

Alternatively, TMAO may increase NAFLD risk by inducing oxidative stress, impairing glucose tolerance, or reducing bile acid synthesis