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This pathway is critical for limiting the build up of harmful intermediates and maximizing protein turnover over short term [4143]

Animal model metabolomics studies reveal that HFD-induced NAFLD is characterized by hepatic saturated fatty acid (myristic acid, palmitic acid) and monounsaturated fatty acid (oleic acid) accumulation, accompanied by decreased gluconeogenic amino acid (glycine, alanine, aspartic acid, glutamic acid, proline) levels (95)

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High GS activity is associated with radioresistance in cancer cells through the regulation of nucleotide metabolism, G2/M recovery and DNA repair [79]

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