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157 PDAC is one of the deadliest cancers, with 75% of patients developing liver metastases within 12 years following original tumor resection

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CDDP-elicited DNA adducts can engender double-strand breaks (DSBs), which are normally repaired along with DNA synthesis (or shortly after) via homologous recombination (HR)

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Pubmed Central PMCID: 2398308
