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Krojer, T., Sawa, J., Huber, R

This pleiotropic profile makes them especially well-suited for the prevention and treatment of complex chronic inflammatory disorders characterized by multifactorial etiologies and highly interconnected signaling networks (Table 1)

Therefore, preserving NPPC viability and function within this harsh environment is paramount for developing effective IDD interventions

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M1 macrophages are pro-inflammatory, useful in the very early stages of healing for clearing debris but destructive if they persist