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First, various concentrations of cortisol were applied to TRT-HU1 Bmal1 -Luc cells to determine the dose-dependent effect of GC on the Bmal1 expression rhythm

[DOI] [Google Scholar] 234.Filipe HP, Henriques J, Reis P, Silva PC, Quadrado MJ, Serro AP

Depleting cellular antioxidants makes ROS more effective at killing cancer cells because this is the traditional treatment strategy for doing so

The solution should be clear once dissolved

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Dose-finding studies are essential to determine not only efficacy but also therapeutic windows, including optimal dosage, route of administration (e.g., oral nanoformulations or intraperitoneal sustained-release systems), and treatment duration for each compound