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PGC-1 and its downstream regulatory factors (NRF-1, NRF-2, and TFAM) play a pivotal role in the regulation of the spinal cord, muscle, and adipose tissue of SOD1-G93A ALS model mice

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Mechanistically, NNMT suppression increased adipose SAM and NAD, upregulated polyamine flux enzymes (ODC, SSAT), and altered histone methylation consistent with a shift toward oxidative metabolism [2]