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In a study published in the American Journal of Clinical Nutrition , researchers gave healthy adults 500mg of vitamin C daily and measured a rise in red blood cell glutathione of nearly 50% within two weeks, compared with baseline (Johnston et al., 1993)

These compounds increase SIRT1 expression or activity, collectively improving hepatic lipid metabolism, insulin signaling, oxidative stress, autophagy, and inflammatory responses, highlighting their strong multi-target pharmacological potential

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