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Country of Origin - India
Oncogene 23 , 679686 (2004)

During this process, PLA particles were colonized by gut microbes, forming surface biofilms and increasing pullulanase activityan enzyme that degrades branched polysaccharidesthe authors suggested this may have broken down PLA into smaller carbon-rich molecules, potentially supporting Bifidobacterium growth, without triggering pathogenic overgrowth or inflammatory responses (Jimnez-Arroyo et al., 2023)

Incidence of nasal tumours in Wistar rats after 28 months of exposure a,b Types of tumour 0 1350 2700 2760 c mg/m 3 mg/m 3 mg/m 3 mg/m 3 Males Squamous cell carcinoma 1/49 1/52 10/53* 16/49*** Adenocarcinoma 0/49 16/52*** 31/53*** 21/49*** Carcinoma in situ 0/49 0/52 0/53 1/49 Females Squamous cell carcinoma 0/50 0/48 5/53 17/53*** Adenocarcinoma 0/50 6/48* 28/53*** 23/53*** Carcinoma in situ 0/50 0/48 3/53 5/53 a From: Woutersen et al
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d , LX-2 cells were transfected with APOL2 WT or APOL2 2A for 6 h and subsequently treated with or without DP (1 M) for 48 h
