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In contrast to the IgM OSE produced by B1 and MZB cells, the role of IgG OSE in atherosclerosis is less clear and may depend on the subtype of IgG

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However, loss-of-function mutations in TREX1 are clearly pathogenic in monogenic diseases such as Aicardi-Goutires Syndrome, but their contribution to complex autoimmune diseases such as SLE still requires more population genetic studies