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[PMC free article: PMC5102000] [PubMed: 26147204] [CrossRef] 286

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Forgeron PA, Finley GA, Arnaout M
In normal cells, HIF-1, which is activated under hypoxic conditions, serves as a potent driver of glucose metabolic reprogramming, particularly within the hypoxic TME [53]

It is a naturally occurring peptide that originates from a protein found in the stomach & has been modified to improve its stability & bioavailability

While chronic elevations in uric acid are associated with increased stroke risk, acute elevations in uric acid may provide some antioxidant protection.25 Uric acid, a final product in the breakdown of purine nucleosides in humans, also appears to help prevent lipid peroxidation if vitamin C is also present.25 A Double-Edged Sword: Antioxidants Dual Nature The devil may be in the dose when it comes to antioxidants
