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10.1016/j.bbadis.2006.03.008 12 BeersD

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The mechanism is aggregation: shear forces cause hydrophobic amino acid residues normally buried inside the peptide structure to flip outward, where they bind to hydrophobic regions on adjacent peptide molecules

In the context of the immune response to HCV, it was discovered that single nucleotide polymorphisms (SNPs) in the IFNL4 gene coding for interferon lambda 4 (IFN4) are associated with disease outcome 43