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To date, two small molecule c-MET inhibitors, cabozantinib and crizotinib, have been approved by regulatory authorities for the treatment of selected cancer types, but several novel c-MET inhibitors (either monoclonal antibodies or small molecule c-MET tyrosine kinase inhibitors) and treatment combinations are currently under study in different settings

A systematic review and meta-analysis of clinical trials

S-nitrosation of mitochondrial connexin 43 regulates mitochondrial function

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While changes in mEPSC amplitude are often postsynaptically driven, increases in cytoplasmic glutamate can increase mEPSC amplitude, while decreased filling of vesicles decreases mEPSC amplitude (2730)