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The authors propose here the new 5R principle, which considers the R ight species, R ight place, R ight time, R ight level, and R ight target. Erythrocytes are organelle-free cells that do not possess mitochondria and peroxisomes

There, Drp1 interacts with key adaptor proteins, including mitochondrial fission protein 1 (FIS1), mitochondrial dynamics proteins 49 and 51 kDa (MiD49 and MiD51), and mitochondrial fission factor (MFF), to drive membrane constriction and division (Smirnova et al., 1998