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Front Immunol (2019) 10:1800

It is advised that patients with confirmed but unexplained iron overload should be referred to a specialist in iron disorders for further assessment

This may be especially relevant when elevated SAH occurs together with a low serum bicarbonate/CO level, impaired kidney function, dehydration, poor circulation, high toxic burden or evidence of mitochondrial dysfunction

Interestingly, both plastic (i.e., reversible) and permanent (i.e., stable) metabolic adaptations have been observed following exposure to anticancer therapeutics

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Further definition of the nature of these gaps will require serial sectioning or FIB/SEM to trace their contours, but similar gaps and distortions can also be seen in non-cryoprotected control brains (data not shown), so we suspect these are artifacts