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9 Immunosenescence is also regulated by signaling pathways such as the nuclear factor-kappa B (NF-B), mTOR, JAK-STAT, melatonin, and sirtuin pathways, whose dysregulation leads to aberrant immune responses and increased susceptibility to age-related diseases

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In addition, the genes KLF2 [81], metallothionein 1 G (MT1G) [82] and KDM5C[83] also play positive roles in preventing or delaying ccRCC development by promoting GSH metabolism and inhibiting lipid peroxidation

Emodin induces ferroptosis in colorectal cancer through NCOA4-mediated ferritinophagy and NF-b pathway inactivation

This approach could position the clinical trials enterprise to develop standard measures of efficiency for clinical trial performance and accelerate systemic reforms [22]