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Numerous metabolites produced by cancer cells, including itaconate, L-kynurenine, lactic acid, and hyaluronic acid, have been demonstrated to activate Nrf2 and play a significant role in regulating the TIME and tumor-TAMs interaction

Physiol-Ren Physiol
347,348 Studies have demonstrated that this method enhances the efficacy of chemotherapeutic agents such as etoposide, paclitaxel (PTX), and DOX, reducing tumor growth and extending survival
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2025 Jan 2:2447620