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(2020) 4:bvaa045
These typically resolve within hours

Hirschey MD, Zhao Y

Noninferiority of mitapivat treatment versus splenectomy in 4.2 / mice and additional benefit of mitapivat in splenectomized 4.2 / mice Splenectomy is the gold standard treatment for symptomatic HS
The matched five-milligram loadings produce a one-to-one ratio across all reconstitution volumes, mirroring the 1:1 dose ratio used in the clinical-trial program

USA 118 , e2108155118 (2021)
