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Immunogenicity The development of factor VIII inhibitors with the use of ADVATE was evaluated in clinical trials with pediatric PTPs ( 5 BU) and nine subjects developed low-titer inhibitors

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71 Cyanocobalamin is associated with worsening of visual problems, and is therefore contraindicated in people with the mitochondrial disorder Lebers hereditary optic neuropathy
Studies should elucidate on the relationship between cancer cell metabolism, TME, and clinical drug efficacy

(3) Large-sample, long-term, real-world observational studies and multi-center, large-sample RCTs on digital or pharmacological therapies for MAFLD/MASH should be conducted nationwide
