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[DOI] [PubMed] [Google Scholar] 46.de Sousa R.T., Zarate C.A., Jr., Zanetti M.V., Costa A.C., Talib L.L., Gattaz W.F., Machado-Vieira R

Higher Death Rates in Ankylosing Spondylitis Save A nationwide study of 8600 ankylosing spondylitis (AS) patients from Sweden, compared survival to 40,460 controls between 2006-2012

This triple mechanism distinguishes it from dual-agonist peptides like tirzepatide (GLP-1/GIP) and single-agonist compounds like semaglutide (GLP-1 only), making it the most broadly acting incretin-class compound currently under clinical investigation