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Lipophagy and intracellular fatty acid accumulation are promoted by ATG14 overexpression and lead to oxidative stress and apoptosis, while inhibition of ATG14 increases cell survival [139]

( C ) Histogram of cell lines ranked by NRF2 activation score (upper) or NRF2 dependency ( NFE2L2 Chronos score) (lower), with the presence or absence of potential NRF2-activating mutations depicted by colour

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Notch pathway activity varies across tumor regions, with higher expression in peritumoral GSCs than in the tumor core, suggesting a role in maintaining stemness and therapeutic resistance

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