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As hair grows, melanin synthesis in the follicle releases high levels of ROS

Molecules 28(3):1447

108 Moreover, the SPHK1 inhibitor PF543 also effectively relieved ERS by reducing the phosphorylation of eIF2 and activating ATF6, thus remarkably improving AIH

In fact, certain types of DNA damaging agents can result in a spectrum of DNA lesions that are handled by different DNA repair pathways, thus it is expected that proteins and enzymes from different pathways may cooperate to remove specific types of DNA damage

(PubMed) Almeida OP, Marsh K, Alfonso H, Flicker L, Davis TM, Hankey GJ