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A lot of guilt and frustration accompanies feeling too unwell to do things that you love, being unable to exercise, and struggling to fully engage in life, which can take a toll on your relationships with friends and family

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Its ability to modulate angiogenesis, inflammation, nitric oxide signaling, neurotransmitters, and tissue-specific repair highlights its pleiotropic nature [20, 2326, 30, 3841]

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A PubMed literature search used keywords, such as amyotrophic lateral sclerosis or ALS, as well as combinations of words using the controlled vocabulary thesaurus feature, Medical Subject Headings (MeSH)