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PMID: 36928818

Despite limited literature on the health effects of chronic xylazine use, regular injection of xylazine has been associated with skin ulcers, abscesses and lesions in Puerto Rico.2 3 Semistructured interviews with people who use xylazine in Puerto Rico revealed that regular use of xylazine leads to skin ulcers.4 As skin ulcers are painful, people may continually inject at the site of the ulcer to alleviate the pain as xylazine is a potent 2-adrenergic agonist that mediates via central 2-receptors, which decreases perception of painful stimuli.1 People may self-treat the wound by draining or lancing it, which can exacerbate negative outcomes.8 While Philadelphia has seen a rise in skin and soft tissue infections relating to injection drug use, it is not yet clear whether or not this is due to increased presence of xylazine in the drug supply.9" Johnson J, Pizzicato L, Johnson C, et al

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K., Wang L., Raykhel I

Visible improvements from GHK-Cu typically begin within 2 to 4 weeks , with more significant changes becoming noticeable after 8 to 12 weeks of consistent use