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We also showed blocking the activation of NFB prevented the increase in GCLC mRNA level induced by buthionine sulfoximine (BSO, an irreversible inhibitor of GCL) and TBH rat hepatocytes (Cai et al., 1997)

10.1021/nn800332g 84 YuX.ZhaoJ.FanD

However, by examining GSH metabolism in a new way, we may be able to identify chronic diseases at the earliest possible stage of development and intervene with low-cost strategies when there is the greatest potential impact to slow down their progression

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