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Conclusion: The study emphasizes P

Redox Biology 41: 101932

This metabolic route is referred to as the delta5-pathway

These compounds do not work through the same pathways

For example, homocysteine-induced endoplasmic reticulum protein, which is located in the ER membrane of neurons and astrocytes in the Central Nervous System (SNC), is found accumulated in Lewy bodies, suggesting a role in their formation and further development of PD [117]

Therefore, targeting the oxidative stress-macrophage polarization axis may break this vicious cycle in SLE-associated AS
