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Neurons require large amounts of energy and metabolize glucosetheir main source of energythrough glycolysis for ATP synthesis [62]

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In addition, through its effect on the RNA-binding capacity of the iron response element binding protein (IRP), DFO decreased FXN transcription and protein production in FRDA cells (Li et al., 2008)

Ethics declarations Ethical approval The animal study protocol was approved by Institutional Ethical Committee of Vellore Institute of Technology (Reg No: VIT/IAEC/18/DEC2020/16)

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