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To allow for possible receptor-site steric hindrance in the design of this study, we selected both the native enzyme dimer and a single GST subunit for docking simulations

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( a ) Overall pathway schematic for relevant metabolites, indicating both labeled and unlabeled species that will be present in the livers

The cell viability (%) was calculated using the following equation: where negative control was defined as 100% viability, and treated sample refer to cell cultures treated with APIs, blank-LPN, and EV-QuerCar, respectively

A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation

Importantly, circulating HTY metabolites, mainly HTY sulfate and HTY glucuronides, reach plasma concentrations several-fold higher than parent HTY and retain cardiovascular-related bioactivity