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E., Malenka, R
Activation here amplifies GH release via the PLC/IP3/Ca pathway and suppresses hypothalamic somatostatin tone, which is the "brake" on GH output
Nrf2 regulates the sensitivity of death receptor signals by affecting intracellular glutathione levels
10.3390/suschem5020004 165 SahuN.SoniD.ChandrashekharB.SatputeD.SaravanadeviS.SarangiB.et al (2016)
In published studies the benefit obtained in adult height was usually less than 4 cm over controls with doses of less than 0.3 mg/kg/week
Thats why clinicians still reach for it decades later
