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There may be implications for liver, kidney, or thyroid function in some individuals

-Carotene isomers in human serum, breast milk and buccal mucosa cells after continuous oral doses of all-trans and 9-cis -carotene

Knocking down LAMP2A significantly induces senescence in primary human fibroblasts, as evidenced by increased senescence-associated -galactosidase activity, ROS production and lipofuscin accumulation (132)

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Among several strategies used to deliver molecules into cells, conjugation with CPPs is a common approach 45,46