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This might not have significant implications for glaucoma pathology since it has been shown that either knocking out NOS-2 on the DBA/2J background or inhibiting NOS-2 with aminoguanidine conferred no protection of RGCs or their axons [63]

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Unlike insulin, glibenclamide, and chlorpropamide, metformin has shown a notable 30% decrease in mortality and complications related to diabetes [18-20]

The endogenous antioxidant defenses, including GSH synthesis, can be regulated by the transcription factor nuclear factor erythroid 2related factor 2 (Nrf2), which plays an essential role in modulating the cellular response against oxidative stress and molecular damage [68,69]