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The membrane was blocked with 3% non-fat milk (BioRad, Hercules, CA, United States) at room temperature for 1.5 h, washed, and incubated with primary antibodies (Supplementary Table 3) at 4C overnight on a rotating shaker

A 7kg terrier and a 40kg Labrador have very different nutritional needs, and giving the same amount to both would leave one under-supported and the other over-supplemented

Depletion of adenosine has been shown to reduce fibrosis, inflammation, and vasculopathy in two preclinical mouse models of SSc 61

P., & Tiano, L

Proper cycling of 5-amino-1MQ prevents tolerance development and allows natural NNMT function to reset

Fundoplication surgery mechanically reinforces the lower esophageal sphincter through a surgical procedure