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Maquart, Pickart, and colleagues established this in fibroblast culture in 1988 ( FEBS Letters ) and confirmed it in vivo in rat wound models in 1993 ( Journal of Clinical Investigation ) 5 6

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Namely, eNOS, iNOS and COX2 activity are thought to be specifically up-regulated in myocardial infarction [38]

In such a case, the ownership percentage of all existing shareholders, including founders and investors, would be diluted unless they choose to increase their shareholding by purchasing more shares