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Intestinal inflammation, dysbiosis, or increased permeability can significantly reduce DAO production and allow dietary histamine to enter circulation unchecked
The expression of the gene encoding heparanase is regulated epigenetically and by tumor suppressor p53, but can also be induced by early growth response stimulation of transcription factor-1, reactive oxygen species, and inflammatory cytokines (64)
For example, Pim2 kinase directly activates glycolysis by phosphorylating glycolytic enzymes PGK1, PDHA1, and PFKFB2, driving M1 polarization in inflammatory arthritis (135)
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doi: 10.1016/j.phrs.2016.05.035 94 WangXXEdelsteinMHGafterUQiuLLuoYDobrinskikhEet al
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