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Subject terms: Medical research, Physiology Abstract (TFLL) , , TFLL, /TFLL, , TFLL () , TFLL, TFLL, , TFLL, , Introduction The tear film is a nourishing, lubricating and protecting layer over the ocular surface, which ensures ocular health and normal vision [1]

Compared with macrophages from wild-type mice, S1PR2-deficient mice eliminate the effects of S1P and SEW2871 on macrophages, 157,159 indicating that S1PR2 contributes to the functions of S1P and SEW2871

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In general pharmacology, titration means making cautious, incremental changes while monitoring tolerance , because faster changes can increase the likelihood of adverse effects

A t -test with unequal variance, followed by multiple testing correction (BenjaminiHochberg false discovery rate [FDR], adjusted p -value), was used to determine significant differences in ion features or metabolites