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According to vitro experiments we can know that the growth of human prostate cancer LNCaP and DU145 cells will also be restricted by curcumin in exhibiting both time-dependent and dose-dependent characteristics, arresting tumor cells at G2 or M phase, significantly elevate the reactive oxygen species (ROS) level in cells, and prompt apoptosis of prostate cancer cells (Chen, 2022)

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Hence, the observed vulnerability to ferroptosis in the context of CDK4/6 inhibition appeared to be independent of DHODH activation (Supplementary Fig

After formulation of this drugCDliposomes, their size was measured to be 67 nm by cryo-TEM

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