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When NNMT activity is high, fat cells become more efficient at lipogenesis, the process of creating and storing fat

Fluid Retention: Full GH therapy commonly causes fluid retention, edema, and associated complications including carpal tunnel syndrome

This dual action promoting fat breakdown while preventing fat formation creates a powerful metabolic environment for fat loss

Gao Y, Van Haren MJ, Buijs N, Innocenti P, Zhang Y, Sartini D, Campagna R, Emanuelli M, Parsons RB, Jespers W (2021b) Potent inhibition of nicotinamide N-methyltransferase by alkene-linked bisubstrate mimics bearing electron deficient aromatics

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